منابع مشابه
NF-κB signaling: Flipping the Switch with Polyubiquitin Chains
Cells respond rapidly to changes in their internal and external environments, often by using post-translational protein modifications to transmit signals from the cell surface or internal sites to the nucleus. These signaling pathways allow cells to respond to growth signals, tolerate stresses or trigger programmed cell death. In general, signaling pathway activation is transient, with feedback...
متن کاملSignalling Functions of Polyubiquitin Chains and Ubiquitin- binding Domains
.................................................................................................................................... 3 Acknowledgement ................................................................................................................. 4 Table of
متن کاملOrchestra for assembly and fate of polyubiquitin chains.
Selective protein degradation by the 26 S proteasome usually requires a polyubiquitin chain attached to the protein substrate by three classes of enzymes: a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin ligase (E3). This reaction can produce different polyubiquitin chains that, depending on size and linkage type, can provide distinct intracellular signal...
متن کاملMechanisms of Generating Polyubiquitin Chains of Different Topology
Ubiquitination is an important post-translational process involving attachment of the ubiquitin molecule to lysine residue/s on a substrate protein or on another ubiquitin molecule, leading to the formation of protein mono-, multi- or polyubiquitination. Protein ubiquitination requires a cascade of three enzymes, where the interplay between different ubiquitin-conjugating and ubiquitin-ligase e...
متن کاملLinkage-specific conformational ensembles of non-canonical polyubiquitin chains.
Polyubiquitination is a critical protein post-translational modification involved in a variety of processes in eukaryotic cells. The molecular basis for selective recognition of the polyubiquitin signals by cellular receptors is determined by the conformations polyubiquitin chains adopt; this has been demonstrated for K48- and K63-linked chains. Recent studies of the so-called non-canonical cha...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2008
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm2508